<%@LANGUAGE="JAVASCRIPT" CODEPAGE="1252"%> Chromosome dynamics Chromosome dynamics

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Austrian Science Fund

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Monthly Meetings

 

Meetings:

Late Summer Meeting
Chromosome Dynamics
September 9-12,2012









Unraveling the Function of Chromosomal Domains

 

Although superficial, the similarity between Miro’s vision and the scientist’s view of the microcosm surrounding our genome is surprising. Yet, to date, our knowledge about chromosomes still resembles more of the picture to the right, threads surrounded by a multitude of objects, with little annotation of their individual identities and functions. This contrasts with our vision, which, similar to the Miro’s vision, postulates a complex pattern of interactions between individually different components (colored objects), which dynamically interact with each other and with the chromosome (thin threads). We believe, that this diversity exists and can be unraveled using state of the art methods at our hands, such as mass spectrometry, microarray tiling analysis and others.
A consortium of 7 groups at the neighboring institutions MFPL (University of Vienna and Medical University) and IMP (Institute of Molecular Pathology) has been funded by the Austrian Science Foundation (FWF) to address the following issues:

  • Improve the diversification of our view of the chromosome (chromosomal domains). Chromosomes are highly structured - well known examples comprise Kinetochores, Telomeres (Nobelprize for Medicine, 2009, for telomerase) and Eu- and Heterochromatin. However, more chromosomal domains exists (e.g. chromosome axis and loops) and require characterization .
  • Increase the knowledge of networks between factors, which affect chromosomes. (proteomes)
  • Establish how these factors interact with the chromosomes (dynamics protein-DNA interaction studies)
  • Compare this in different organisms (including fungal, plant, and animal model systems)