VORLESUNG “PHARMAZEUTISCHE WIRKSTOFFENTWICKLUNG“ (LV 270071, WS 2017/18)

Dr. Martin Hintersteiner, Prof. Dr. Christian Becker   

 

 

BEGINN DER VORLESUNG, 12.12., 8.30 Uhr, Seminarraum 2

 

Die Vorlesung wird in zwei Blöcken angeboten:

 

 

1. Block:

12.12. im Seminarraum 2 (1. Stock, Währinger Str. 42): 8.30-10.00
13.12. im Seminarraum 1: 8.30-10. und dann 10.45-13.00 im Seminarraum 2
14.12 im Seminarraum 2: 8.30-10
15.12. im Seminarraum 4: 9.00 - 13.00

 

2. Block:

Seminarraum 4: 15.1. und 16.1., jeweils 9-12 Uhr, 17.1., 10-12 Uhr

Eventuell zusätzlicher Termin (nach Bedarf) am 18.1., 9-12 Uhr, Seminarraum 4

 

Mündliche Prüfungstermine zur VL (für das WS 2016!): Dienstag, 16.01., 12-14 Uhr, Seminarraum 4.

Anmeldung über u-space vom 14.12., 8 Uhr bis 14.01., 12 Uhr.

Abmeldung bis 15.01.,12 Uhr.

 

 

Inhalt der Vorlesung: Drug discovery is highly interdisciplinary drawing from Chemistry, Biology and Biophysics. We look at: 1. Drug Discovery: Drug discovery in industry & in academia ; What are the process steps in Drug discovery and Development; Classes of Drug targets; High-throughput screening and other methods to identify starting points; Assay types and characterization, Fluorenscence - essential tool in drug discovery; Chemistry and properties of fluorescent dyes; 2. Druglikeness: What drugs look like and how they act; Hit - lead - drug properties and predictions; 3. Drug development strategies: Drug classes and their development hurdles; Approaches for optimization of drug properties; Medicinal chemistry at work - examples; Thermodynamics of ligand-receptor interactions; In-vitro profiling and non-linear curve fitting; 4. Drug delivery & in-vivo profiling: Strategies for drug delivery; Preclinical in-vivo characterization of drug candidates, ADME; Clinical development; 5. Scale-up for industrial production: Process design, scale-up, methodologies; 6. Regulatory aspects and Quality systems in the pharmaceutical & food industry: Registration process, FDA & EMA, Principles of quality systems, GMP, GLP in the working environment.

 

 

Lecture/Day 1

Lecture/Day 2

Lecture/Day 3