Purpose: The text searches for possible uses of a daring postulate to reject dualism, formulated by Josef Mitterer. Furthermore, it explores the inconsistencies of dualism and its remnants in three projects: Richard Rorty’s neopragmatism, the strong program of the sociology of knowledge, and radical constructivism. The final aim of the argument is to demonstrate that a very interesting incorporation of Mitterer’s postulates is possible, and that it must take the form of a consistent antiessentialism. At this point the article presents Bruno Latour’s actor-network theory. Findings: The article underlines the specific role of the so-called other side of the discourse – which, according to Mitterer is fabricated by the dualizing mode of speaking. Such an instance is a priori essentialized and it plays a crucial role as a tool for settling arguments. The text traces the role of this instance in the concepts mentioned above. Benefits: Through the use of Latour’s constructivism, the text indicates that there exists a fruitful empirical (non-speculative) research program, which was projected in accordance with Mitterer’s postulates.