VU University Amsterdam
Main building VU University Amsterdam
De Boelelaan 1105
1081 HV Amsterdam
Ever since it was founded in 1880, VU University Amsterdam has been known for its distinctive approach to knowledge. VU is an open organization, strongly linked to people and society. What matters is not just the acquisition of a greater depth of knowledge, but also a wider one. We ask and expect our students, researchers, PhD candidates and employees to look further – to look further than their own interests and their own field, and further than what is familiar and further than the here and now.
The mission of the Division of Molecular Toxicology is to develop novel and innovative concepts involved in drug disposition and drug safety assessment. Integration of advanced computational and experimental approaches is hereby the key, while the focus is on molecular mechanisms of drug metabolism and toxicity.
Our research involves cytochromes P450 (CYPs, P450s) and other selected drug targets, such as the estrogen receptor (ER). The division is aiming to be leading in this field and to be an attractive partner for cooperation as well as an attractive host for master students, PhD students and post-docs. Currently, we focus on three distinct but strongly interrelated research-lines: biotransformation and bioactivation, computational medicinal chemistry and toxicology, and cellular signalling and toxicity.
Key staff involved:
Professor Nico Vermeulen graduated in Chemistry in 1975 at the Radboud University Nijmegen. In 1980, he obtained his PhD in Pharmacology from Leiden University. He was appointed professor of Molecular Toxicology at VU University Amsterdam in 1985. He organizes the yearly Dutch post-academic course on general toxicology, and the yearly international LACDR/EUFEPS course on high-throughput drug metabolism and disposition.
Dr. Daan Geerke graduated cum laude in Chemistry and Pharmacochemistry at VU University Amsterdam in 2003, with specializations in Theoretical Chemistry and Computational Medicinal Chemistry & Toxicology. Subsequently, he performed his PhD research at the Swiss Federal Institute of Technology in Zurich under supervision of Professor Van Gunsteren. He obtained his PhD degree in 2007 on the development of classical force fields and combined quantum/molecular mechanical methods for use in biomolecular simulation.