Freie Universität Berlin
Kaiserswerther Str. 16-18
Freie Universität Berlin was founded in 1948 by professors and students, in response to the persecution faced by students who took a critical eye of the system at Universität Unter den Linden, at that time located in the Soviet sector of the divided city. The idea of founding a free university found widespread support in the international community, including financial support. This outpouring of aid helped pave the way for Freie Universität to become a university with an outstanding international reputation. The principles of freedom and internationality have guided the university’s development ever since. Since the university’s founding, in December of 1948, the academic ethos of Freie Universität Berlin has always been defined by three values: truth, justice, and freedom.
Our research deals with the in-silico prediction of biological effects of small organic molecules for drug design. Using all different kinds of available and established molecular modeling methods like docking, similarity searches, homology modeling and molecular dynamics we try to identify novel hits and optimize lead structures.
Drug action is rarely explained by an interaction with one single biological target, but by hitting several targets and pathways. Instead of virtually screening a large amount of molecules against one single potential target, we screen with one single (or a few) molecules against a large set of models to better understand the activity profile of already existing drugs or newly discovered drug candidates.
Key staff involved:
Research interests: Development of algorithms and methods for simulating target/drug interaction, efficient virtual screening tools & cheminformatics. Experimental validation and application of new techniques for drug development. Early drug discovery and risk assessment during the drug discovery process.