Inflammatory and infectious diseases, arising usually from either insufficient or exacerbated immune responses, have been in recent years increasingly studied using animal models that employ gene-targeted mice. Without doubt, this approach has improved our understanding of human disorders. However, in order to obtain a more comprehensive knowledge about human diseases that may at some point result in novel treatments a more integrative approach is needed. The phenotype of animals used in infectious and inflammatory disease models should be examined by using both targeted experiments as well as high throughput and systems biology methods. Only the combination of these approaches will reveal potentially relevant changes in expression profiles, posttranslational protein modifications, or metabolic pathways. Such an integrative research is still underdeveloped and there is clearly a need to facilitate its further expansion. The FEBS-EFIS Inflammation 2010 Workshop address all these issues by presenting experimental models for inflammatory and infectious diseases, regulatory mechanisms controlling gene expression with a strong emphases on epigenetic mechanisms and regulatory non-coding RNAs, and high throughput and system biology approaches covering gene expression profiling, posttranslational modifications in inflammation and infection. The selected topics will be represented by experienced and renowned scientists that are leading in their areas of research. Thus, premium science on timely topics will be presented to the workshop participants (PhD students and early postdocs).