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Workshop Summary

Inflammatory and infectious diseases, arising usually from either insufficient or exacerbated immune responses, have been in recent years increasingly studied using animal models that employ gene-targeted mice. Without doubt, this approach has improved our understanding of human disorders. However, in order to obtain a more comprehensive knowledge about human diseases that may at some point result in novel treatments a more integrative approach is needed. The phenotype of animals used in infectious and inflammatory disease models should be examined by using both targeted experiments as well as high throughput and systems biology methods. Only the combination of these approaches will reveal potentially relevant changes in expression profiles, posttranslational protein modifications, or metabolic pathways. Such an integrative research is still underdeveloped and there is clearly a need to facilitate its further expansion. The FEBS-EFIS Inflammation 2010 Workshop address all these issues by presenting experimental models for inflammatory and infectious diseases, regulatory mechanisms controlling gene expression with a strong emphases on epigenetic mechanisms and regulatory non-coding RNAs, and high throughput and system biology approaches covering gene expression profiling, posttranslational modifications in inflammation and infection. The selected topics will be represented by experienced and renowned scientists that are leading in their areas of research. Thus, premium science on timely topics will be presented to the workshop participants (PhD students and early postdocs).


Oreste Acuto, University of Oxford, Oxford, UK
Laurence Arbibe, Institute Pasteur, Paris
Simon C Arthur, University of Dundee, Dundee, UK
Adelheid Cerwenka, German Cancer Research Center, Heidelberg, Germany
Gerard Eberl, Institute Pasteur, Paris, France
Sabine Ehrt, Weill Cornell Medical College, New York, USA
Steffen Jung, The Weizmann Institute of Science, Rehovot, Israel
Wolf-Dietrich Hardt, ETH Zürich, Zürich, Switzerland
Mathias Hornef, Institute of Medical Microbiology, Hannover, Germany
David Hume, The Roslin Institute, Edinburgh, UK
Roland Lang, University of Erlangen, Erlangen, Germany
Ofer Mandelboim, The Hebrew University, Jerusalem, Israel
Mihai Netea, Radboud University Nijmegen, The Netherlands
Capucine Picard, University Paris René Descartes, Paris, France
Tom van der Poll, University of Amsterdam, The Netherlands
Alice Prince, Columbia University, New York, USA
Felix Randow, University of Cambridge, Cambridge, UK
Simona Saccani, Max Planck Institute, Freiburg, Germany
Maya Saleh, McGill University, Montreal, Canada
Brigitta Stockinger, MRC, Mill Hill, London, UK
Giuseppe Teti, University of Messina, Italy
Jeffrey Weiser, University of Pennsylvania, Philadelphia, USA
Keji Zhao, National Institutes of Health, Bethesda, USA