Molecular Systems Biology

Research groups

Wolfram Weckwerth | Curriculum Vitae - Publications ...

Wolfram Weckwerth

Development of genome-wide metabolomics and proteomics/phosphoproteomics technologies as elementary systems biology techniques, high throughput profiling (HTP) in systems biology, data integration; combining experimental approaches with multivariate statistics, pattern recognition and modeling of metabolism: "synergetics" in plants, animals and microbes.

Development of theoretical models based on multivariate statistics for the biological interpretation of HTP data, recalculation of biochemical regulation – the "Jacobian" - from HTP data plant genotype-phenotype interaction; plant phenotypic plasticity including stress, growth, developmental and nutritional physiology

Metabolomics and proteomics – assisted genome annotation and reconstruction of genome-wide metabolic and regulatory networks in plant, microbial and other model systems like Arabidopsis thaliana (dicot), Chlamydomonas reinhardtii (green alga), Medicago truncatula (legume) and others, applications of metabolomics and proteomics to non-sequenced species like tomato, potato, plant communities, microbiomes etc.

Personalzed medicine: metabolomic and proteomic analysis of biofluids, data integration and physiology

Databases, data management and data mining

Stefanie Wienkoop | Curriculum Vitae - Publications ...

Stfanie Wienkoop

Plant Sytems Interaction

The group around Stefanie Wienkoop is investigating the effects of symbiotic microbe interactions on the plants response to abiotic and biotic stress.

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Markus Teige | Curriculum Vitae - Publications ...

Markus Teige

Plant Signalling

His group ist studying how plants adapt and acclimate to a changing environment or to stress conditions. How are environmental signals perceived and further processed in plants, and which processes are regulated?

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Thomas Naegele | Curriculum Vitae - Publications ...

Volker Egelhofer

Research Focus:
Molecular System Dynamics The experimental high-throughput analysis of cellular systems has become an integral part of biological research.Concomitantly, the interpretation of the resulting complex data sets with respect to biochemical regulation and physiological traits lags far behind. The group's research focus addresses the question how to link such experimental high-throughput data to underlying biochemical and signalling networks, their regulation and related physiological traits. The compilation of our biochemical, physiological and high-throughput techniques are combined with a framework of biomathematical operations ultimately aiming at the detection and characterisation of cellular and organismal outputs.

Key techniques which are applied in the group:
Metabolomics (see also: ViMe - Vienna Metabolomics Center)
Subcellular fractionation techniques
Enzyme kinetics
Mathematical modeling of metabolic networks
Multivariate Statistics

Projects:
- in situ studies of Arabidopsis thaliana populations (Project Homepage)
- Regulation of primary metabolism under oxidative stress (Project Homepage)
- MERIT - Metabolic Reprogramming by Induction of Transcription (Project Homepage)

Doris Engelmeier | Gert Bachmann | Wolfgang Postl

Doris Engelmeier

This group tackels the physiological aspects (physiolome) within the Division of Molecular Systems Biology in a very modern way. This embraces help in conduction of experiments like installing measurement equipment (e.g. soil moisture, statistics, ....).

Measurements concerning the so called "SPAC" [Soil-Plant-Atmosphere-Continuum] including "SRI" [Soil Root Interface] SPAC is the pathway for water moving from soil through plants to the atmosphere. This comprises soil physics, physiology of plants (animals), ion uptake and microclimatolog as well as electrochemistry (Voltammetry) of root exudates and plant extracts.

Teaching several practical classes concerning plant physiology, plant anatomy, plant mineral nutrients, rhizosphere, statistics and soil agenda respectively.

The recently available photosynthetic measurement system including a gas exchange (GFS-3000 system) and Imaging PAM (both from Walz) offers accurate and solid accompanying classical physiological measurements like photosynthesis, transpiration, chlorophyll-fluorescence, etc..

Imaging PAM (Walz)

GFS-3000 Gas exchange system (Walz)

Soil sensors (moisture)
GP2 Datalogger (Delta-T)
Datalogger DL2e (Delta-T)

Computrace Voltammography (Metohm 797)

"Phyto-Qi-Lab"

Cationic HPLC (Metrohm 881 pro)

"Phyto-QI" - Lab outside
measuring micoclimate and several photosynthetic parameters during a pratical class

Prototype of a dripping irrigation system for drought stress studies