Molecular Systems Biology
Wolfram Weckwerth | Curriculum Vitae - Publications ...
Development of genome-wide metabolomics and proteomics/phosphoproteomics technologies as elementary systems biology techniques, high throughput profiling (HTP) in systems biology, data integration; combining experimental approaches with multivariate statistics, pattern recognition and modeling of metabolism: "synergetics"
Development of theoretical models based on multivariate statistics for the biological interpretation of HTP data, recalculation of biochemical regulation – the "Jacobian" - from HTP data plant genotype-phenotype interaction; plant phenotypic plasticity including stress, growth, developmental and nutritional physiology
Metabolomics and proteomics – assisted genome annotation and reconstruction of genome-wide metabolic and regulatory networks in plant, microbial and other model systems like Arabidopsis thaliana (dicot), Chlamydomonas reinhardtii (green alga), Medicago truncatula (legume) and others, applications of metabolomics and proteomics to non-sequenced species like tomato, potato, plant communities, microbiomes etc.
Personalzed medicine: metabolomic and proteomic analysis of biofluids, data integration and physiology
Databases, data management and data mining
Stefanie Wienkoop | Curriculum Vitae - Publications ...
The group around Stefanie Wienkoop is dealing with the systemic analysis of plants. To gain insight into plant systems, the research group focus on the crosslinking between metabolic networks using mass spectrometry (metabolomics and proteomics) as a major tool.
One central topic is the comparative analysis of different abiotic and allelopathic stress factors in legumes such as Lotus japonicus, Medicago truncatula, Garden- and Soybean as well as Pea.
Biological questions are the interaction, regulation and adaptation of metabolic networks and growth processes of different plant tissues (leaf, root, nodule) to unravel the influence of changing environmental conditions also in respect to symbiotic plant-microbe interactions.
Environmental changes and interferences are affecting a complex metabolic network thus influencing the interaction of a whole system.
Plants are sessile life forms that have to adapt to these continuously changing environmental conditions. Those changes can be caused due to diurnal rhythm and abiotic factors such as temperature, light, water and nutrition supply. Plants are considered stressed if reduction in growth or reproduction is caused dependent upon load. Applications of targeted and non-targeted analyses are being used. The non-targeted approach allows for the comprehensive and unbiased analysis of metabolic pathways, which enables detection of novel physiologicallyrelevant metabolites and proteins that uncovers new regulatory mechanisms and complex network connections. The complementary targeted analysis allows for the determination of absolute concentrations the study on subcellular localisation, post translational modifications etc. of selected metabolites and proteins belonging to an interacting metabolic pathway.
Markus Teige | Curriculum Vitae - Publications ...
His group ist studying how plants adapt and acclimate to a changing environment or to stress conditions. How are environmental signals perceived and further processed in plants, and which processes are regulated?
Volker Egelhofer | Curriculum Vitae - Publications ...
Metabolic Information Server (MIS): an integrated platform for Proteomic and Metabolomic Studies
Metmex: Mass Spectral Database for Metabolome Analysis
Promex: Public library for protein reference spectra
Protmax: a quantitative proteomics software tool for analyzing shotgun proteomics mass spectrometry data sets.
Enzyme classification, metabolic network reconstruction,metabolic network analysis
Modelling metabolic networks: fba, differential equation, statistics
Development of algorithms to improve the prediction of protein function based on protein sequence information