Contact:

University of Vienna
Dept for Molecular Systems Biology
1090 Vienna, Austria
Phone + 43-1-4277-577 00
e-mail: wolfram.weckwerth@univie.ac.at

 

Projects:

 

 

 

 

 

• Solanaceae Pollen Thermotolerance (SPOT-ITN) ... more

• Metabolic Reprogramming by Induction of Transcription... more

RESEARCH INTERESTS

• Development of genome-wide metabolomics and proteomics/phosphoproteomics technologies as elementary systems biology techniques, high throughput profiling (HTP) in systems biology, data integration; combining experimental approaches with multivariate statistics, pattern recognition and modeling of metabolism: "synergetics"
• development of theoretical models based on multivariate statistics for the biological interpretation of HTP data, recalculation of biochemical regulation – the "Jacobian" - from HTP data
• plant genotype-phenotype interaction; plant phenotypic plasticity including stress, growth, developmental and nutritional physiology
• personalzed medicine: metabolomic and proteomic analysis of biofluids, data integration and human physiology
• metabolomics and proteomics – assisted genome annotation and reconstruction of genome-wide metabolic and regulatory networks in plant, microbial and other model systems like Arabidopsis thaliana (dicot), Chlamydomonas reinhardtii (green alga), Medicago truncatula (legume) and others, applications of metabolomics and proteomics to non-sequenced species like tomato, potato, plant communities, microbiomes etc.
• databases, data management and data mining

Detailed CV

14.4.1969	Born in Berlin
1988	Abitur
1988-1993	Studies of chemistry at Technical University Berlin
1994	Diploma thesis on "Biosynthesis of Taxol and Bouvardin" at Technical University Berlin
1994-1998	Ph.D. thesis on " Biosynthesis of cyclooctadepsipeptides in fungi - PF1022A", Supervisor PD Dr. Rainer Zocher and Prof. Dr. Horst Kleinkauf at Technical University Berlin
1999-2000	Postdoctoral research associate at Technical University Berlin, research on peptide antibiotika and Taxol biosynthesis
2000-2001	Max Planck Stipendium, Research in the Metabolomics group of Oliver Fiehn at Max-Planck-Institute of Molecular Plant Physiology, Department Lothar Willmitzer
2001-2002	Postdoctoral research associate in the Metabolomics group of Oliver Fiehn at Max-Planck-Institute of Molecular Plant Physiology, Department Lothar Willmitzer
since 2002	Research Group Leader: "Integrative Metabolomics and Proteomics" at Max-Planck-Institute of Molecular Plant Physiology, Department Mark Stitt
since 2005	Extended scope of functions: "Development and application of methods in metabolomics, quantitative proteomics and phosphoproteomics, bioinformatics and systems biology" at Max-Planck-Institute of Molecular Plant Physiology, Department Mark Stitt
2006/7	Habilitation University Potsdam; venia legendi "Molecular Plant Physiology and Systems Biology"
Since 2007	Head of one of the Central Research Groups "Systems Biology", GoFORSYS, Bundesministerium für Bildung und Forschung BMBF
Since 2007	Lecturer for Systems Biology at the University of Potsdam
2007/8	Offer for Professorship University Vienna and Michigan State University
since 2008	Full Professor and head of the Department for Molecular Systems Biology (MoSys) at the University of Vienna

 

 

Professional Duties and Functions

• Austrian Representative for the European Plant Proteomics COST action (http://www.costfa0603.com/)
• Chairman of MASCP (Multi-National Arabidopsis Steering Committee Proteomics
  (http://www.masc-proteomics.org/)
• Co-Chair of the Metabolomics Committee MASC
• Member of the Steering Committee of the systems biology programme GoFORSYS
• Editorial Board of the Journal of Personalized Medicine, Frontiers of Plant Physiology, Frontiers of Plant Proteomics, Proteomics Insights, Cell Biology Insights and Open Spectroscopy Journal
• AIST-Fellow (Advanced Industrial Science and Technology, Tsukuba, Japan)
• Advisory boards: Institute of Science and Technology Austria (ISTA) advisory board for the selection of group leader positions 2009, NATO Science Series I: Life and Behavioural Sciences 2004 "Genomics for Biosafety in Plant Biotechnology, Sofia 2004; European Systems Biology (EUSYSBIO) Foresight Workshop, Heidelberg, 2005; Dynamics of Aquatic Chemical Ecology, Wilhelmshaven, 2006; Experimentelle und theoretische Metabolomforschung - metabolische Netze, Köln, 2006, BMBF Systems Biology Call 2009, Berlin, Germany
• Editor of the first edition "Metabolomics: Methods and Protocols", in the series "Methods in Molcular Biology", Humana Press 2007

Conference Organization

• Organization of the first Metabolomics Conference Austria, InMetA (International Metabolomics Austria) in Vienna, September 2010
• Organization of the MASC-Proteomics Workshop in Beijing, China, International Arabidopsis Conference 2007, 2009

Publications

Books

"Metabolomics: Methods and Protocols." Methods in Molecular Biology 358. Humana Press. Edited by Wolfram Weckwerth. (Oktober 2006)

 

Peer-reviewed and review publications: http://www.ncbi.nlm.nih.gov/pubmed)

Patents

• Combined metabolomic, proteomic and transcriptomic analysis from one, single sample and suitable statistical evaluation of data
  Inventors: Weckwerth Wolfram, Fiehn Oliver
• Method for the production of baccatin-III by enzymatic synthesis
  Inventors: M Hoffmann, W Weckwerth, K Glund, and R Zocher
  Publication info: US6458568
• Production of taxanes useful as anti-tumour agents
  Inventors: D Ewald, W Weckwerth, K Becker, K Glund, H Derdulla, C Hacker, K Haeupke, H Roensch, and R Zocher
  Publication info: DE19623338

Invited national and international talks since 2002

• Mass spectrometry Methods in Proteomics 2002. Free University Berlin, Germany.
  Title: Stable isotope labelling for quantitative proteomics.
• Summerschool Proteomics. Canacale, Turkey 2002.
  Title: Biochemical Networks and quantitative proteomics.
• Institute of Plant Biochemistry. Halle, Germany 2003.
  Title: Shotgun Proteomics.
• NATO Advanced Research Workshop. Genomics for Biosafety: New Challenges. Bansko, Bulgaria 2003.
  Title: Biochemical Profiling in Plant Systems.
• Potential of Metabolic Profiling in Plant Science. Turin, Italy 2003.
  Title: Integrating Metabolomics and Proteomics in Plant Systems Biology.
• Plant Proteomics Workshop. Samuel Roberts Noble Foundation, Ardmore, Oklahoma, USA 2004.
  Title: Plant proteomics embedded in dynamic metabolic networks – an integrative approach.
• Gordon Research Conference Macromolecular Organization & Cell Function. Queen´s College, Oxford, UK 2004.
  Title: Metabolic networks and their structural characteristics at a plant-systems level.
• Genomes to Systems. 2nd Conference. The Consortium for Post-Genome Science. Manchester, UK 2004.
  Title: Causal connectivities in metabolomic networks: An integrative approach.
• The 14th FESPB Congress (Federation of European Societies of Plant Biology). Cracow, Poland 2004.
  Title: Differential Metabolic Correlation Networks in Plant Physiology.
• Summer School 2004, DFG Research Training Group "Communication in Biological Systems". Hirschegg, Germany.
  Title: Structural principles in biochemical networks at a systems level.
• Proteomics Workshop Thermoelectron. Berlin, Germany 2004.
  Title: Plant Proteomics.
• Plant Research International Institute. Wagningen, Netherlands 2005.
  Title: GC-TOF-MS metabolite profiling in Arabidopsis thaliana.
• Proteomics Workshop "Protnet" Jena, Germany 2005.
  Title: Shotgun proteomics in plants.
• Semestervortrag Universität Rostock, Germany 2005.
  Titel: Integration of metabolomics and proteomics based on mass spectrometry and multivariate data mining.
• Symposium Metabolomics IPK Gatersleben, Germany 2005.
  Title: Systems biology in plants.
• Society of Experimental Biology, Barcelona, Spain 2005.
  Title: Signalling and plant proteomics.
• International Congress of Botany, Vienna, Austria 2005.
  1. Session Metabolic Profiling: Metabolomics and proteomics in Arabidopsis thaliana– integration improves pattern recognition and biological interpretation.
  2. Session Nonlinear Dynamics: Metabolomics or How to find  causal connectivity in metabolic networks?
• International Arabidopsis Conference Madison, Wisconsin, USA 2005.
  Title: Metabolomics and proteomics in Arabidopsis thaliana– transitions from pattern recognition to biological interpretation.
• European Network Summerschool, Ljubljana, Slowenia 2005.
  Title: Mass Spectrometry - a major tool for functional genomics research.
• DFG SPP Workshop "Dynamics of Chemically Mediated Interaction Webs in Aquatic Communities: Regulation, Variability and Plasticity.", Wilhelmshaven, Germany 2005.
• DFG SPP Workshop "Experimentelle und theoretische Metabolomforschung - metabolische Netze", Köln, Germany 2005.
• Leibniz Institute of Plant Biochemistry, Halle, Germany 2005.
  Title: Metabolomics and proteomics in Arabidopsis thaliana– integration improves pattern recognition and biological interpretation.
• Deutsche Gesellschaft für Massenspektrometrie (DGMS), Mainz, Germany 2006.
  Keynote lecture: "Massenspektrometrie im Zeitalter der Systembiologie: Metabolit- und Protein-Profilanalyse in biologischen Modellsystemen"
• "MassSpecNet", FU Berlin, Germany 2006.
  Title: "Qualitative and quantitative protein phosphorylation analysis using liquid chromatography coupled to fast scanning ion trap and triple quadrupole mass spectrometry."
• Yokohama Riken Institute, Japan 2006
  Workshop on "Plant Metabolomics and Functional Genomics.
  Title: Mass spectrometry and Systems biology: Integration of metabolomics, proteomics and multivariate data mining reveals insights into systemic responses of a biochemical network."
• Kyoto Research Technology Institute, internal Seminar organized by Nobuo Tanaka, Japan 2006
  Title: "High-resolution chromatography coupled to mass spectrometry and application in metabolomics and proteomics."
• 4th International Conference on Plant Metabolomics, Reading, UK 2006
  Title: "Integration of metabolomics and proteomics based on mass spectrometry and multivariate data mining: Can we learn from the systems-approach?"
• University of Vienna, Department Ecology and Ecosystem Research, Austria 2006
• DKFZ Heidelberg, "MSClub", Germany 2006
• The 3rd International Workshop on Biochips and Environmental Monitoring, Osaka, Japan 2006, invited AIST-Fellow (Advanced Industrial Science and Technology, Tsukuba)
• IPK Gatersleben, Germany 2006
• Deutsch-Tunesischer Workshop "Plants and Bioinformatics", Tunesien 2006
• Missouri Plant Biology Symposium on Protein Phosphorylation, USA, 2007
• Departmental Seminar, Cornell University, USA, 2007
• Symposium "Comprehensive Gas Chromatography-Time-of-Flight Mass Spectrometry in Biomedical Research", University Regensburg, Germany, 2007
• International Arabidopsis Conference China, 2007
• Hinxton UK, British society of proteome research, 2007
• München Martinsried, Arbeitstagung Proteomics, 2007
• Deutsche Gesellschaft für Massenspektrometrie Tagung, Bremen, Germany, 2007
• Proteomics Workshop, Bremen, 2007
• Göttinger Proteomics Forum, Göttingen MPI, Germany, 2007
• Botanisches Colloquium, LMU München, Germany, 2007
• Institutsseminar Polnische Akademie der Wissenschaften, Posen, Polen 2007
• Seminar Mass spectrometry in Life Science, Warschau, Polen, 2007
• Robert-Koch-Institut, Berlin, Germany, 2007
• European Plant Proteomics Conference, Cordoba, Spain2008
• Grand Opening Event, Thermo Proteomics Seminar, Basel, 2008
• FORSYS BMBF, Forschungseinrichtungen fuer Systembiologie in Deutschland, Berlin, Germany, 2008
• NUGO meeting, European network for nutrigenomics, Munich, Germany, 2008
• IRTG, international research training group, Germany-USA-Japan, Genomics and Systems Biology of molecular networks, Berlin, Germany, 2008
• Molecular interactions, Berlin, Germany, 2008
• URGV Plant genomics research unit, Paris, France, 2008
• Austrian platform proteomics, Seefeld, Österreich, 2008
• European Proteomics Seminar Series, Thermo Fisher Scientific, Kunsthistorisches Museum Wien, Österreich, 2008
• Center for Systems Biology, University of Warwick, UK, 2008
• International Conference for Peptide Chemistry, Shenzen China, 2008 – abgesagt
• Metabolomics Symposium, Dalian China, 2008 – abgesagt
• 8th international plant metabolism symposium, Jeju Island, Korea, 2008 – abgesagt, confirmed for next year
• KEYNOTE speaker, Proteomlux, Luxemburg, 2008

• 14 talks in 2009, (Italian Proteomics Association; Plant GEM 2009 Lisbon; Proteomics Symposium University of Florida; International Conference on Plant Abiotic Stress Tolerance Vienna and others)

External funding

	Funding source	Grant title	Grant is a collaborative grant with...	Period covered	Total volume (EUR)
1	MPG	Institutsübergreifende Forschungsinitiative Arabidopsis-Proteomprojekt	Tina Romeis, Berlin	2002-2006	242.800
2	BMBF	BMBF "Nutrigenomics": "Allergenicity in crop plants"	Charité Berlin, Proteome Factory and IGZ Grossbeeren	2005-2008	900.000 (AG Weckwerth 200.000)
3	BMBF	BMBF "Quantpro": Innovative diagnostic tools to optimise potato breeding: Systemic analysis of cellular processes and their relation to plant internal oxygen concentrations	Peter Geigenberger, Joost van Dongen, Potsdam	2006-2009	1.472.000 (AG Weckwerth 250.000)
4	DFG	DFG "Photorespiration and metabolite profiling"	Hermann Bauwe, University Rostock	2006-2008	100.000
5	BMBF	Forschungseinrichtungen fuer Systembiologie in Deutschland (FORSYS)	GoFORSYS consortium, Potsdam	2007-2012	13 million (AG Weckwerth 3.369.000)
6	DFG	Analyse der Sekundärmodifikationen der Phytochrom-Signaltransduktion	Mathias Zeidler, Göttingen	2009-2010	70.000
7	DFG/GENAU	Eranet Plant Genomics PATHONET	Irute Mieskene, Universität Wien, Cyril Zipfel, UK, Dirk Scheel, Germany	2009-2012	1.1 million (AG Weckwerth 220.000)
8	BMBF	Plant-KBBE SEPSAPE	Emilio Montesinos, Spain, Uwe Sonnewald, Germany	2009-2012	2 million (AG Weckwerth 250.000)
9	Leibniz Instituts Förderung	Gemüseallergene: Detektion, Analyse und Steuerung im modernen Gartenbau	Phillip Franken, Germany, Margitta Worm Germany, Christian Scheler, Germany	2009-2012	1.1 million (AG Weckwerth 250.000)
10	BASF			2009-2010
11	BDI		Michael Schagerl, University of Vienna	2009-2010
				TOTAL (AG Weckwerth own contribution)	5.1 million