Members

Group leaders

a.o.Univ.Prof.Mag.Dr. Franz GABOR

a.o.Univ.Prof.Mag.Dr. Michael WIRTH

PhD students

Mag. Elisabeth ENGLEDER
Mag. Lukas NEUTSCH
Mag. Xueyan WANG

Diploma students

Stephanie Deinhammer
Britta Eggenreich
Astrid Fischer
Ariane Foadi
Ingrid Kaniak
Alice Kiwek
Julia Klement
Romana Koller
Michaela Kubal
Sandra Kubin
Elisabeth Lang
Bettina Luser
Regina Nowotny
Clara Pichl
Katharina Senesch
Michael Wambacher
Eva-Maria Wirth

Former members

Mag. Dr. Christian FILLAFER
Mag. Dr. Vera KERLETA

Mag. Dr. Verena PLATTNER

Mag. Dr. Gerda RATZINGER

SMART DRUG DELIVERY

Recent advances in biotechnology yield myriads of promising drug candidates with delicate molecular structure but poor bioavailability. The challenge is to manufacture smart delivery systems which protect but also release the drug at the desired site of action and/or absorption. Ongoing from recent knowledge collected about the basic mechanisms of the lectin-cell interaction, wheat germ agglutinin-grafted and labelled biodegradable micro- and nanoparticles as well as soluble macromolecular prodrug-systems are being characterised in terms of their capacity to mediate mucoadhesion, cytoadhesion, cytoinvasion, and improved transcellular transport. At this, special emphasis is given to the influence of the preparation process, the payload, and the surface modification on the characteristics of the particles. Furthermore, in collaboration with groups from the University of Vienna, the Medical University, the Technical University of Vienna, the Biophysics group at the University of Augsburg, Eindhoven Technical University, and industrial partners, the utility of birch- and grass pollen loaded microparticles for treatment of allergies, the concept of re-loading scaffolds with drug-containing nanoparticles exploiting biorecognition, the interaction of lectinised nanoparticles with human artificial intestinal tissue under flow conditions, the influence of surfactants on the nanoparticle cell-interaction, and the potential of Gadolinium-loaded nanoparticles for diagnostic purposes is being investigated.

 

Methods

HPLC, field flow fractionation, high shear homogenisation, ultrafiltration, atomic force microscopy, fluorescence microscopy and staining techniques, flow cytometry, dynamic light scattering, zeta potential determination, human cell culture models

 

Funding

1997 - 1999
Einfluss der Herstellungsparameter auf die Größencharakteristik und das Freigabeprofil von wirkstoffhältigen Poly-(d,l-lactid-co-glycolid) Mikrosphären
OENB Nr. 65 96

1999 - 2002
Accelerated drug development by real time kinetic studies
FWF - P-13513 MED

2004
Nahrungsergänzungsmittel zur Behebung der Histaminintoleranz
FFG – Nr. 80 83 89

2004 - 2008
CellPROM – Cell programming by nanoscaled devices
EU- FP6

2007 - 2008
A formulation containing Xyloseisomerase
FFG – Nr. 816418

2008 - 2009
Caricol Resorption
FFG – Nr. 819695