Members

Group leader

a.o.Univ.Prof.Mag.Dr.
Claudia Valenta

PhD students

Mag. Victoria KLANG
Mag. Corinna NAGELREITER
Mag. Julia SCHWARZ

Diploma students

Regina WINKLER
Sandra KARALL
Silvia HABERFELD
Sophie KREPCIK
Magdalena HOPPEL
Angelika WEIXELBAUM

 

Former

Mag. Dr. Sonja HÖLLER

Mag. Dr. Amra HASANOVIC

 

• Home / News
• Department
  • Location
  • Administration
• Staff
• Research
  • Topical drug delivery systems
  • Cell culture models in preclinical biopharmaceutics
  • Smart Drug Delivery
  • Innovative concepts in pharmaceutical technology
  • Biopharmaceutics of bone and cartilage
• For Students
  • Prüfungstermine
  • Lehrveranstaltungen
  • Lehrinhalte
• Links

TOPICAL DRUG DELIVERY SYSTEMS

(Arzneistoffabgabesysteme zur topischen Applikation)

 

Our mission

The possibility of applying drugs dermally offers fundamental advantages compared to other routes of application. Among those are the avoidance of the first pass effect which occurs after oral application of drugs or negative side effects often induced by parenteral application. The development of dermally applicable systems is therefore of great interest.

Research focuses on the design and optimisation of dermally applied drug delivery systems. Lecithin based nanoemulsions with sugar surfactants, liposomal formulations coated with different polymers, gelified microemulsions as well as polymer nanoparticles are interesting and promising vehicles in terms of skin compatibility and drug permeation.

Our objective is to acquire a better understanding of the factors controlling skin permeation of drugs. By using in vitro models and physico-chemical analysis, interactions between model drugs and formulations are investigated and their influence on topical delivery is determined. Knowledge and understanding of the relationships between vehicle, drug and skin allow for the design of new optimised drug delivery systems.

 

Major topics

Improvement of penetration and permeation of drugs through skin

Development and testing of polymers and modified polymers as matricesfor topical drug delivery systems

Liposomes, nanoemulsions, microemulsions, cubic phases

Methods

Skin diffusion

• Tape stripping, Franz-cells, human skin, porcine skin

Bio-FTIR

• Interaction skin  - drug delivery system

Microcalorimetry

• Characterisation
• Interaction of possible penetration enhancers with model membranes

Analytics

• UV/VIS, fluorescence, HPLC/diode array, HPLC/fluorescence, FTIR, rheometer, particle size, zeta potential

 

Funding