Mag. Denise MARHAUSER
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TOPICAL DRUG DELIVERY SYSTEMS
(Arzneistoffabgabesysteme zur topischen Applikation)
The possibility of applying drugs dermally offers fundamental advantages compared to other routes of application. Among those are the avoidance of the first pass effect which occurs after oral application of drugs or negative side effects often induced by parenteral application. The development of dermally applicable systems is therefore of great interest.
Research focuses on the design and optimisation of dermally applied drug delivery systems. Lecithin based nanoemulsions with sugar surfactants, liposomal formulations coated with different polymers, gelified microemulsions as well as polymer nanoparticles are interesting and promising vehicles in terms of skin compatibility and drug permeation.
Our objective is to acquire a better understanding of the factors controlling skin permeation of drugs. By using in vitro models and physico-chemical analysis, interactions between model drugs and formulations are investigated and their influence on topical delivery is determined. Knowledge and understanding of the relationships between vehicle, drug and skin allow for the design of new optimised drug delivery systems.
Improvement of penetration and permeation of drugs through skin
Development and testing of polymers and modified polymers as matricesfor topical drug delivery systems
Liposomes, nanoemulsions, microemulsions, cubic phases
- Tape stripping, Franz-cells, human skin, porcine skin
- Interaction skin - drug delivery system
- Interaction of possible penetration enhancers with model membranes
- UV/VIS, fluorescence, HPLC/diode array, HPLC/fluorescence, FTIR, rheometer, particle size, zeta potential
Evaluation of the possible use of phloretin and derivatives as well as ketocholestanol and derivatives as enhancers/retarders for skin penetration/permeation http://www.fwf.ac.at
Funded by the pharmaceutical industry, INTENDIS company (Austria)
Chemical and physical investigations of basic vehicles for topical application
Funded by the pharmaceutical industry, AESCA company (Austria)
Skin permeation from microemulsions and cubic gels
C. Valenta is leader of the Research Platform
Funded by the pharmaceutical industry, BAYER company (Austria)
Stability testing of dermal preparations
Simultaneous determination of the skin penetration of drug and vehicle compounds by 19F-NMR and assessment of their interaction with the skin by ATR-FTIR spectroscopy