Members

Group leader

a.o.Univ.Prof.Mag.Dr.
Claudia Valenta

 

PhD students

Mag. Magdalena HOPPEL

Mag. Corinna NAGELREITER

Mag. Denise MAHRHAUSER

 

Diploma students

Lisa BINDER

Hanna ETTL

Evelyn HOLPER

Eva KRATOCHVILOVA

Zahra MARAVANDI

Judith SCHÖLL

Florian WAGNER

 

Former

Mag. Dr. Sonja HÖLLER

Mag. Dr. Amra HASANOVIC

Mag. Dr. Victoria KLANG

Mag. Dr. Julia SCHWARZ

 

TOPICAL DRUG DELIVERY SYSTEMS

(Arzneistoffabgabesysteme zur topischen Applikation)

 

Our mission

The possibility of applying drugs dermally offers fundamental advantages compared to other routes of application. Among those are the avoidance of the first pass effect which occurs after oral application of drugs or negative side effects often induced by parenteral application. The development of dermally applicable systems is therefore of great interest.

Research focuses on the design and optimisation of dermally applied drug delivery systems. Lecithin based nanoemulsions with sugar surfactants, liposomal formulations coated with different polymers, gelified microemulsions as well as polymer nanoparticles are interesting and promising vehicles in terms of skin compatibility and drug permeation.

Our objective is to acquire a better understanding of the factors controlling skin permeation of drugs. By using in vitro models and physico-chemical analysis, interactions between model drugs and formulations are investigated and their influence on topical delivery is determined. Knowledge and understanding of the relationships between vehicle, drug and skin allow for the design of new optimised drug delivery systems.

 

Major topics

Improvement of penetration and permeation of drugs through skin

Development and testing of polymers and modified polymers as matricesfor topical drug delivery systems

Liposomes, nanoemulsions, microemulsions, cubic phases

Methods

Skin diffusion

  • Tape stripping, Franz-cells, human skin, porcine skin, Fingerprint Sensor

Bio-FTIR

  • Interaction skin  - drug delivery system

Non invasive

  • TEWL, pH, skin hydration, sebum content

Microcalorimetry

  • Characterisation
  • Interaction of possible penetration enhancers with model membranes

Analytics

  • UV/VIS, fluorescence, HPLC/diode array, HPLC/fluorescence, FTIR, rheometer, particle size, zeta potential

 

Funding

2001-2004
FWF P125137
Evaluation of the possible use of phloretin and derivatives as well as ketocholestanol and derivatives as enhancers/retarders for skin penetration/permeation http://www.fwf.ac.at

2005-2007
§27-project

Funded by the pharmaceutical industry, INTENDIS company (Austria)

Chemical and physical investigations of basic vehicles for topical application

 

2005-2009
§27-project
Funded by the pharmaceutical industry, AESCA company (Austria)

Skin permeation from microemulsions and cubic gels


C. Valenta is leader of the Research Platform

Characterisation of drug involved mechanisms

http://drugmechanism.univie.ac.at/

2011-2014
§27-project

Funded by the pharmaceutical industry, BAYER company (Austria)

Stability testing of dermal preparations

 

2012-2015
FWF P24846-B20

Simultaneous determination of the skin penetration of drug and vehicle compounds by 19F-NMR and assessment of their interaction with the skin by ATR-FTIR spectroscopy

http://www.fwf.ac.at/asp/projekt_res.asp