Pharmacology Of Bone
Funding:
§27 Projekt (01/2009-12/2010)
§27-Projekt (10/2011-10/2013)
Hochschuljubilaums-stiftung- AD0078621 (01/2006-12/2009)
Research projects:
Development of new bone biomaterials
Investigation of osteoclast function in estrogen-dependent and chemokine dependent conditions in transgenic mouse models
Selectivity and conductance of sodium and calcium channels
Inhibition of osteoclastic bone resorption to study potential new drugs
Effect of drugs on osteoblast function as indicator for the stimulation of bone formation
Group members:
- Dr.Oskar Hoffmann
- Xenia Ulrich
- Kanthi Lewis
Selected publications
2009
- Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis.
Binder NB, Niederreiter B, Hoffmann O, Stange R, Pap T, Stulnig TM, Mack M, Erben RG, Smolen JS, Redlich K.
Nat Med. read more >>
2007
- Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice.
Manetti F, Santucci A, Locatelli GA, Maga G, Spreafico A, Serchi T, Orlandini M, Bernardini G, Caradonna NP, Spallarossa A, Brullo C, Schenone S, Bruno O, Ranise A, Bondavalli F, Hoffmann O, Bologna M, Angelucci A, Botta M.
J Med Chem. 2007 Nov. read more >>
- TNF-induced structural joint damage is mediated by IL-1.
Zwerina J, Redlich K, Polzer K, Joosten L, Kroenke G, Distler J, Hess A, Pundt N, Pap T, Hoffmann O, Gasser J, Scheinecker C, Smolen JS, van den Berg W, Schett G.
Proc Natl Acad Sci U S A. read more >>
Graduate program "Molecular Drug Targets"