Selectivity and conductance of sodium and calcium channels

The rapid and selective transport of ions through ion channels is essential for initiating action potentials within excitable cells. The mechanisms of how these channels discriminate between different ion types and how ions permeate the pores of sodium and calcium channels are poorly understood.
By applying full atomistic molecular dynamics simulations on recently solved high resolutions structures of bacterial sodium channels the mechanism of ion selectivity and conductance is investigated in detail.

Funding:
FWF doctoral program "Molecular Drug Targets" grant W1232

 

  • Group members:
  • Dr. Anna Weinzinger (Group leader, MolTag faculty member)

 

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