Univ. Prof. Dr. Steffen Hering

Head of Department

E-mail: steffen.hering@univie.ac.at
Phone: +43 1 4277 55310
Fax: +43 1 4277 9553

Address:
Department of Pharmacology and Toxicology
University of Vienna
Althanstrasse 14, 2D 349
A-1090 Vienna, Austria


Selected publications

    2017
  • Andranovits S, Beyl S, Hohaus A, Zangerl-Plessl EM, Timin E, Hering S. (2017) Key role of segment IS4 in Cav1.2 inactivation: link between activation and inactivation. Pflugers Arch. Aug 1. doi: 10.1007/s00424-017-2038-3. [Epub ahead of print] read more >>
  • Saxena P, Hortigon-Vinagre MP, Beyl S, Baburin I, Andranovits S, Iqbal SM, Costa A, IJzerman AP, Kügler P, Timin E, Smith GL, Hering S. (2017) Correlation between human ether-a-go-go-related gene channel inhibition and action potential prolongation. Br J Pharmacol. 2017 Sep;174(18):3081-3093. doi: 10.1111/bph.13942.Epub 2017 Aug 11. read more >>
  • Moradi-Afrapoli F, van der Merwe H, De Mieri M, Wilhelm A, Stadler M, Zietsman PC, Hering S, Swart K, Hamburger M. (2017) HPLC-Based Activity Profiling for GABAA Receptor Modulators in Searsia pyroides Using a Larval Zebrafish Locomotor Assay. Planta Med. Oct;83(14-15):1169-1175. doi: 10.1055/s-0043-110768. Epub 2017 May 16. read more >>
  • Li J, Casteels T, Frogne T, Ingvorsen C, Honoré C, Courtney M, Huber KV, Schmitner N, Kimmel RA, Romanov RA, Sturtzel C, Lardeau CH, Klughammer J, Farlik M, Sdelci S, Vieira A, Avolio F, Briand F, Baburin I, Májek P, Pauler FM, Penz T, Stukalov A, Gridling M, Parapatics K, Barbieux C, Berishvili E, Spittler A, Colinge J, Bennett KL, Hering S, Sulpice T, Bock C, Distel M, Harkany T, Meyer D, Superti-Furga G, Collombat P, Hecksher-Sørensen J, Kubicek S. (2017) Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity. Cell. 2017 Jan 12;168(1-2):86-100.e15. doi:10.1016/j.cell.2016.11.010. Epub 2016 Dec 1. read more >>
    2016
  • Tobias Linder, Harald Bernsteiner, Priyanka Saxena, Florian Bauer, Thomas Erker, Eugen Timin, Hering S., Anna Stary-Weinzinger. Drug trapping in hERG K+ channels: (not) a matter of drug size? Med. Chem. Commun., 2016,7, 512-518 read more >>
  • P. Saxena, E.-M. Zangerl-Plessl, T. Linder, A. Windisch, A. Hohaus, E. Timin, Hering S., A. Stary-Weinzinger. New potential binding determinant for hERG channel inhibitors. Scientific Reports 6, Article number: 24182 read more >>
  • Beyl S, Hohaus A, Andranovits S, Timin E, Hering S. Upward movement of IS4 and IIIS4 is a rate-limiting stage in Cav1.2 activation. Pflugers Arch. 2016 Nov;468(11-12):1895-1907. Epub 2016 Oct 29. read more >>
  • Kratz JM, Mair CE, Oettl SK, Saxena P, Scheel O, Schuster D, Hering S, Rollinger JM. Pick your poison: hERG-blocking alkaloids in the emetic herbal drug ipecac. Planta Med. 2016 Dec;81(S 01):S1-S381. No abstract available. read more >>
  • Khom S, Hintersteiner J, Luger D, Haider M, Pototschnig G, Mihovilovic MD, Schwarzer C, Hering S. Analysis of β-Subunit-dependent GABAA Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives. J Pharmacol Exp Ther. 2016 Jun;357(3):580-90. doi: 10.1124/jpet.116.232983. read more >>
  • Kratz JM, Mair CE, Oettl SK, Saxena P, Scheel O, Schuster D, Hering S, Rollinger JM. hERG Channel Blocking Ipecac Alkaloids Identified by Combined In Silico - In Vitro Screening. Planta Med. 2016 Jul;82(11-12):1009-15. doi: 10.1055/s-0042-105572. read more >>
    2015
  • Luger D, Poli G, Wieder M, Stadler M, Ke S, Ernst M, Hohaus A, Linder T, Seidel T, Langer T, Khom S, Hering S. Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis. Br J Pharmacol. 2015 Sep 16. read more >>
    2014
  • Structural insights into trapping and dissociation of small molecules in K+ channels Linder T, Saxena P, Timin E, Hering S, Stary-Weinzinger A, J Chem Inf Model. 2014 Oct 21. read more >>
  • Experimentally validated hERG pharmacophore models as cardiotoxicity prediction tools. Kratz JM, Schuster D, Edtbauer M, Saxena P, Mair CE, Kirchebner J, Matuszczak B, Baburin I, Hering S, Rollinger JM. J Chem Inf Model. 2014 Aug 22 read more >>
  • Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives. Schöffmann A*, Wimmer L*, Goldmann D*, Khom S, Hintersteiner J, Baburin I, Schwarz T, Hintersteininger M, Pakfeifer P, Oufir M, Hamburger M, Erker T, Ecker GF, Mihovilovic MD, Hering S. J Med Chem. 2014 Jul 10;57(13):5602-19. doi: 10.1021/jm5002277. Epub 2014 Jun 27. *Authors contributed equally read more >>
  • Esters of valerenic acid as potential prodrugs. Hintersteiner J, Haider M, Luger D, Schwarzer C, Reznicek G, Jäger W, Khom S, Mihovilovic MD, Hering S. Eur. J. Pharmacol. 735,123–131 read more >>
  • Identification of dihydrostilbenes in Pholidota chinensis as a new scaffold for GABAA receptor modulators. Rueda DC, Schöffmann A, De Mieri M, Raith M, Jähne EA, Hering S, Hamburger M. Bioorg. Med. Chem. 22, 1276–1284 read more >>
  • A cycloartane glycoside derived from Actaea racemosa L. modulates GABAA receptors and induces pronounced sedation in mice. Strommer B, Khom S, Kastenberger I, Cicek CC, Stuppner H, Schwarzer C, Hering S. J Pharmacol Exp Ther jpet. 114.218024; published ahead of print August 26, 2014 read more >>
    2013
  • GABAA receptor modulation by piperine and a non-TRPV1 activating derivative. Khom S, Strommer B, Schöffmann A, Hintersteiner J, Baburin I, Erker T, Schwarz T, Schwarzer C, Zaugg J, Hamburger M, Hering S Biochem Pharmacol. 2013 Apr read more >>
    2012
  • Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of Ca(V)1.2: a cooperative gating model. Beyl S, Depil K, Hohaus A, Stary-Weinzinger A, Linder T, Timin E, Hering S. Pflugers Arch. read more >>
  • HPLC-based activity profiling--discovery of sanggenons as GABAA receptor modulators in the traditional Chinese drug Sang bai pi (Morus alba root bark). Kim HJ, Baburin I, Zaugg J, Ebrahimi SN, Hering S, Hamburger M. Planta Med. 2012 Mar. read more >>
  • GABA(A) receptor modulators from the Chinese herbal drug Junci Medulla--the pith of Juncus effusus. Singhuber J, Baburin I, Khom S, Zehl M, Urban E, Hering S, Kopp B. Planta Med. 2012 Mar. read more >>
  • Discovery of GABA(A) receptor modulator aristolactone in a commercial sample of the Chinese herbal drug "Chaihu" (Bupleurum chinense roots) unravels adulteration by nephrotoxic Aristolochia manshuriensis roots. Rueda DC, Zaugg J, Quitschau M, Reich E, Hering S, Hamburger M. Planta Med. 2012 Feb. read more >>
  • GABA(A) receptor modulators from Chinese herbal medicines traditionally applied against insomnia and anxiety. Singhuber J, Baburin I, Kählig H, Urban E, Kopp B, Hering S. Phytomedicine. 2012 Feb. read more >>
    2011
  • Identification of GABA A receptor modulators in Kadsura longipedunculata and assignment of absolute configurations by quantum-chemical ECD calculations. Zaugg J, Ebrahimi SN, Smiesko M, Baburin I, Hering S, Hamburger M. Phytochemistry. 2011 Dec. read more >>
  • Timothy mutation disrupts link between activation and inactivation in CaV1.2. Depil K, Beyl S, Stary-Weinzinger A, Hohaus A, Timin E, Hering S. J Biol Chem. read more >>
  • Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. Singhuber J, Baburin I, Ecker GF, Kopp B, Hering S. Eur J Pharmacol. 2011 Oct. read more >>
  • Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice. Zaugg J, Khom S, Eigenmann D, Baburin I, Hamburger M, Hering S. J Nat Prod. 2011 Aug. read more >>
  • Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship. Taferner B, Schuehly W, Huefner A, Baburin I, Wiesner K, Ecker GF, Hering S. J Med Chem. 2011 Aug. read more >>
  • Positive GABA(A) receptor modulators from Acorus calamus and structural analysis of (+)-dioxosarcoguaiacol by 1D and 2D NMR and molecular modeling. Zaugg J, Eickmeier E, Ebrahimi SN, Baburin I, Hering S, Hamburger M. J Nat Prod. 2011 Jun. read more >>
  • HPLC-based activity profiling of Angelica pubescens roots for new positive GABAA receptor modulators in Xenopus oocytes. Zaugg J, Eickmeier E, Rueda DC, Hering S, Hamburger M. Fitoterapia. 2011 Apr. read more >>
  • HERG channel inhibitors in extracts of Coptidis rhizoma. Schramm A, Baburin I, Hering S, Hamburger M. Planta Med. 2011 May. read more >>
  • HPLC-based activity profiling for GABA(A) receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root). Yang X, Baburin I, Plitzko I, Hering S, Hamburger M. Mol Divers. 2011 Jan 5. read more >>
    2010
  • Trapping and dissociation of propafenone derivatives in HERG channels. Windisch A, Timin E, Schwarz T, Stork-Riedler D, Erker T, Ecker G, Hering S. Br J Pharmacol. 2010 Dec 22 read more >>
  • Bioactivity-guided isolation of GABA(A) receptor modulating constituents from the rhizomes of Actaea racemosa. Cicek SS, Khom S, Taferner B, Hering S, Stuppner H. J Nat Prod. 2010 Dec. read more >>
  • Interaction of diltiazem with an intracellularly accessible binding site on Ca(V) 1.2. Shabbir W, Beyl S, Timin E, Schellmann D, Erker T, Hohaus A, Hockerman G, Hering S. Br J Pharmacol. read more >>
  • Physicochemical properties of pore residues predict activation gating of Ca V1.2: a correlation mutation analysis. Beyl S, Depil K, Hohaus A, Stary-Weinzinger A, Timin E, Shabbir W, Kudrnac M, Hering S. Pflugers Arch. read more >>
  • Cysteines in the loop between IS5 and the pore helix of CaV3.1 are essential for channel gating. Karmazinova M, Beyl S, Stary-Weinzinger A, Suwattanasophon C, Klugbauer N, Hering S, Lacinova L. Pflugers Arch. read more >>
  • Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization. Khom S, Strommer B, Ramharter J, Schwarz T, Schwarzer C, Erker T, Ecker GF, Mulzer J, Hering S. Br J Pharmacol. read more >>
  • The hERG potassium channel and drug trapping: insight from docking studies with propafenone derivatives. Thai KM, Windisch A, Stork D, Weinzinger A, Schiesaro A, Guy RH, Timin EN, Hering S, Ecker GF. ChemMedChem. read more >>
  • HPLC-based activity profiling for GABA(A) receptor modulators: a new dihydroisocoumarin from Haloxylon scoparium. Li Y, Plitzko I, Zaugg J, Hering S, Hamburger M. J Nat Prod. 2010 Apr. read more >>
  • HPLC-based activity profiling: discovery of piperine as a positive GABA(A) receptor modulator targeting a benzodiazepine-independent binding site. Zaugg J, Baburin I, Strommer B, Kim HJ, Hering S, Hamburger M. J Nat Prod. read more >>
    2009
  • Different pathways for activation and deactivation in CaV1.2: a minimal gating model. Beyl S, Kugler P, Kudrnac M, Hohaus A, Hering S, Timin E. J Gen Physiol. read more >>
  • Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2. Kudrnac M, Beyl S, Hohaus A, Stary A, Peterbauer T, Timin E, Hering S. J Biol Chem. read more >>
    2008
  • Pore stability and gating in voltage-activated calcium channels. Hering S, Beyl S, Stary A, Kudrnac M, Hohaus A, Guy HR, Timin E. Channels read more >>
  • Molecular dynamics and mutational analysis of a channelopathy mutation in the IIS6 helix of Ca V 1.2. Stary A, Kudrnac M, Beyl S, Hohaus A, Timin EN, Wolschann P, Guy HR, Hering S. Channels read more >>
  • Structural model of the Ca V 1.2 pore. Stary A, Shafrir Y, Hering S, Wolschann P, Guy HR. Channels read more >>
  • Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits. Baburin I, Khom S, Timin E, Hohaus A, Sieghart W, Hering S. Br J Pharmacol. read more >>
  • HPLC-based activity profiling approach for the discovery of GABAA receptor ligands using an automated two microelectrode voltage clamp assay on Xenopus oocytes. Kim HJ, Baburin I, Khom S, Hering S, Hamburger M. Planta Med. read more >>
  • Proliferation of aligned mammalian cells on laser-nanostructured polystyrene. Rebollar E, Frischauf I, Olbrich M, Peterbauer T, Hering S, Preiner J, Hinterdorfer P, Romanin C, Heitz J. Biomaterials. read more >>
  • Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. Trauner G, Khom S, Baburin I, Benedek B, Hering S, Kopp B. Planta Med. read more >>
    2007
  • State dependent dissociation of HERG channel inhibitors. Stork D, Timin EN, Berjukow S, Huber C, Hohaus A, Auer M, Hering S. Br J Pharmacol. read more >>
  • Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity. Khom S, Baburin I, Timin E, Hohaus A, Trauner G, Kopp B, Hering S. Neuropharmacology. read more >>
  • Probing the architecture of an L-type calcium channel with a charged phenylalkylamine: evidence for a widely open pore and drug trapping. Beyl S, Timin EN, Hohaus A, Stary A, Kudrnac M, Guy RH, Hering S. J Biol Chem. read more >>
    2006
  • Automated fast perfusion of Xenopus oocytes for drug screening. Baburin I, Beyl S, Hering S. Pflugers Arch. read more >>
  • Simple and versatile methods for the fabrication of arrays of live mammalian cells. Peterbauer T, Heitz J, Olbrich M, Hering S. Lab Chip. read more >>
  • Pharmacological properties of GABAA receptors containing gamma1 subunits. Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S. Mol Pharmacol. read more >>
  • Combined transplantation of skeletal myoblasts and angiopoietic progenitor cells reduces infarct size and apoptosis and improves cardiac function in chronic ischemic heart failure. Bonaros N, Rauf R, Wolf D, Margreiter E, Tzankov A, Schlechta B, Kocher A, Ott H, Schachner T, Hering S, Bonatti J, Laufer G. J Thorac Cardiovasc Surg. read more >>
    2005
  • Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorder. Hohaus A, Beyl S, Kudrnac M, Berjukow S, Timin EN, Marksteiner R, Maw MA, Hering S. J Biol Chem. read more >>
  • A CACNA1F mutation identified in an X-linked retinal disorder shifts the voltage dependence of Cav1.4 channel activation. Hemara-Wahanui A, Berjukow S, Hope CI, Dearden PK, Wu SB, Wilson-Wheeler J, Sharp DM, Lundon-Treweek P, Clover GM, Hoda JC, Striessnig J, Marksteiner R, Hering S, Maw MA. Proc Natl Acad Sci U S A read more >>