Dr. Sophia Khom

E-mail: sophia.khom@univie.ac.at
Phone: +43 1 4277
Fax: +43 1 4277 9553

Department of Pharmacology and Toxicology
University of Vienna
Althanstrasse 14,
A-1090 Vienna, Austria

Selected publications

  • Khom S, Hintersteiner J, Luger D, Haider M, Pototschnig G, Mihovilovic MD, Schwarzer C, Hering S. Analysis of β-Subunit-dependent GABAA Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives. J Pharmacol Exp Ther. 2016 Jun;357(3):580-90. doi: 10.1124/jpet.116.232983. read more >>
  • Luger D, Poli G, Wieder M, Stadler M, Ke S, Ernst M, Hohaus A, Linder T, Seidel T, Langer T, Khom S, Hering S. Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis. Br J Pharmacol. 2015 Sep 16. read more >>
  • Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives. Schöffmann A*, Wimmer L*, Goldmann D*, Khom S, Hintersteiner J, Baburin I, Schwarz T, Hintersteininger M, Pakfeifer P, Oufir M, Hamburger M, Erker T, Ecker GF, Mihovilovic MD, Hering S. J Med Chem. 2014 Jul 10;57(13):5602-19. doi: 10.1021/jm5002277. Epub 2014 Jun 27. *Authors contributed equally read more >>
  • Esters of valerenic acid as potential prodrugs. Hintersteiner J, Haider M, Luger D, Schwarzer C, Reznicek G, Jäger W, Khom S, Mihovilovic MD, Hering S. Eur. J. Pharmacol. 735,123–131 read more >>
  • A cycloartane glycoside derived from Actaea racemosa L. modulates GABAA receptors and induces pronounced sedation in mice. Strommer B, Khom S, Kastenberger I, Cicek CC, Stuppner H, Schwarzer C, Hering S. J Pharmacol Exp Ther jpet. 114.218024; published ahead of print August 26, 2014 read more >>
  • GABAA receptor modulation by piperine and a non-TRPV1 activating derivative. Khom S, Strommer B, Schöffmann A, Hintersteiner J, Baburin I, Erker T, Schwarz T, Schwarzer C, Zaugg J, Hamburger M, Hering S Biochem Pharmacol. 2013 Apr read more >>
  • GABA(A) receptor modulators from the Chinese herbal drug Junci Medulla--the pith of Juncus effusus. Singhuber J, Baburin I, Khom S, Zehl M, Urban E, Hering S, Kopp B. Planta Med. 2012 Mar. read more >>
  • Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice. Zaugg J, Khom S, Eigenmann D, Baburin I, Hamburger M, Hering S. J Nat Prod. 2011 Aug. read more >>
  • Bioactivity-guided isolation of GABA(A) receptor modulating constituents from the rhizomes of Actaea racemosa. Cicek SS, Khom S, Taferner B, Hering S, Stuppner H. J Nat Prod. 2010 Dec. read more >>
  • Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization. Khom S, Strommer B, Ramharter J, Schwarz T, Schwarzer C, Erker T, Ecker GF, Mulzer J, Hering S. Br J Pharmacol. read more >>
  • Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits. Baburin I, Khom S, Timin E, Hohaus A, Sieghart W, Hering S. Br J Pharmacol. read more >>
  • HPLC-based activity profiling approach for the discovery of GABAA receptor ligands using an automated two microelectrode voltage clamp assay on Xenopus oocytes. Kim HJ, Baburin I, Khom S, Hering S, Hamburger M. Planta Med. read more >>
  • Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. Trauner G, Khom S, Baburin I, Benedek B, Hering S, Kopp B. Planta Med. read more >>
  • Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity. Khom S, Baburin I, Timin E, Hohaus A, Trauner G, Kopp B, Hering S. Neuropharmacology. read more >>
  • Pharmacological properties of GABAA receptors containing gamma1 subunits. Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S. Mol Pharmacol. read more >>