ao.Univ. Prof. Mag. Dr. Rosa Lemmens-Gruber

Phone: +43 1 4277 55325
Fax: +43 1 4277 9553

Department of Pharmacology and Toxicology
University of Vienna
Althanstrasse 14, 2D 257
A-1090 Vienna, Austria

Selected publications

  • Heilos D, Rodríguez-Carrasco Y, Englinger B, Timelthaler G, van Schoonhoven S, Sulyok M, Boecker S, Süssmuth RD, Heffeter P, Lemmens-Gruber R, Dornetshuber-Fleiss R, Berger_W. The Natural Fungal Metabolite Beauvericin Exerts Anticancer Activity In Vivo: A Pre-Clinical Pilot Study. Toxins (Basel). 2017 Aug 24;9(9). pii: E258. doi: 10.3390/toxins9090258. read more >>
  • Willam A, Aufy M, Tzotzos S, El-Malazi D, Poser F, Wagner A, Unterköfler B, Gurmani D, Martan D, Iqbal SM, Fischer B, Fischer H, Pietschmann H, Czikora I, Lucas R, Lemmens-Gruber R, Shabbir W. TNF Lectin-Like Domain Restores Epithelial Sodium Channel Function in Frameshift Mutants Associated with Pseudohypoaldosteronism Type 1B. Front Immunol. 2017 May 29;8:601. doi: 10.3389/fimmu.2017.00601. eCollection 2017. read more >>
  • Iqbal SM, Lemmens-Gruber R. Voltage gated ion channels blockade is the underlying mechanism of BIMU8 induced cardiotoxicity. Toxicol Lett. 2017 Aug 5;277:64-68. doi:10.1016/j.toxlet.2017.05.024. Epub 2017 May 25. read more >>
  • Willam A, Aufy M, Tzotzos S, Evanzin H, Chytracek S, Geppert S, Fischer B, Fischer H, Pietschmann H, Czikora I, Lucas R, Lemmens-Gruber R, Shabbir W. Restoration of Epithelial Sodium Channel Function by Synthetic Peptides in Pseudohypoaldosteronism Type 1B Mutants. Front Pharmacol. 2017 Feb 24;8:85. doi: 10.3389/fphar.2017.00085. eCollection 2017. read more >>
  • Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I. The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit. J Biol Chem. 2016 Nov 4;291(45):23440-23451. Epub 2016 Sep 19. read more >>
  • Iqbal SM, Andavan GS, Lemmens-Gruber R. Differential modulation of fast inactivation in cardiac sodium channel splice variants by Fyn tyrosine kinase. Cell Physiol Biochem. 2015;37(3):825-37. doi: 10.1159/000430211. Epub 2015 Sep 18. read more >>
  • Shabbir W, Tzotzos S, Bedak M, Aufy M, Willam A, Kraihammer M, Holzner A, Czikora I, Scherbaum-Hazemi P, Fischer H, Pietschmann H, Fischer B, Lucas R, Lemmens-Gruber R. Glycosylation-dependent activation of epithelial sodium channel by solnatide. Biochem Pharmacol. 2015 Dec 15;98(4):740-53. doi: 10.1016/j.bcp.2015.08.003. Epub 2015 Aug 5. read more >>
  • Dornetshuber-Fleiss R, Heilos D, Mohr T, Richter L, Süssmuth RD, Zlesak M, Novicky A, Heffeter P, Lemmens-Gruber R, Berger_W. The naturally born fusariotoxin enniatin B and sorafenib exert synergistic activity against cervical cancer in vitro and in vivo. Biochem Pharmacol. 2015 Feb 1;93(3):318-331. doi: 10.1016/j.bcp.2014.12.013. Epub 2014 Dec 31. read more >>
  • Calpain-mediated integrin deregulation as novel mode of action for the anticancer gallium compound KP46. Jungwirth U, Gojo J, Tuder T, Walko G, Holcmann M, Schöfl T, Nowikovsky K, Wilfinger N, Schoonhoven S, Kowol CR, Lemmens-Gruber R, Heffeter P, Keppler BK, Berge_r W. Mol Cancer Ther. 2014 Jul 31. read more >>
  • A Novel TNF-mediated Mechanism of Direct Epithelial Sodium Channel Activation. Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R. Am J Respir Crit Care Med, 2014 Jul 16 read more >>
  • Mechanism of action of novel lung oedema therapeutic AP301 by activation of ENaC. Shabbir W, Scherbaum-Hazemi P, Tzotzos S, Fischer B, Fischer H, Pietschmann H, Lucas R, Lemmens-Gruber R. Mol Pharm. 84:899-910, 2013 read more >>
  • Sex-Specific-differences in cardiometabolic risk in Type-1-Diabetes. Kautzky-Willer A, Stich K, Hintersteiner J, Kautzky A, Kamyar MR, Saukel J, Johnson BJ, Lemmens-Gruber R. Cardiovasc Diabetol. 12:78, 2013 read more >>
  • Destruxins: fungal-derived cyclohexadepsipeptides with multifaceted anticancer and antiangiogenic activities. Dornetshuber R, Heffeter P, Mohr T, Hazemi P, Seger C, Berge_r W, Lemmens-Gruber R. Biochem Pharmacol 86:361-77, 2013 read more >>
  • AP301, a synthetic peptide mimicking the lectin-like domain of TNF-α, enhances amiloride-sensitive Na+ current in primary dog, pig and rat alveolar type II cells. Tzotzos S, Fischer B, Fischer H, Pietschmann H, Lucas R, Dupré G, Lemmens-Gruber R, Prymaka V, Hazemi P, Shabbir W. Pulm Pharmacol Ther. 26:356-63, 2013 read more >>
  • Voltage-gated sodium channels: mutations, channelopathies and targets. Andavan GS, Lemmens-Gruber R. Curr Med Chem. read more >>
  • Essential structural features of TNF-α lectin-like domain derived peptides for activation of amiloride-sensitive sodium current in A549 cells. Hazemi P, Tzotzos SJ, Fischer B, Andavan GS, Fischer H, Pietschmann H, Lucas R, Lemmens-Gruber R. J Med Chem. read more >>
  • Evidence-based intravenous pain treatment with analgesic infusion regimens. Nemec K, Cihal P, Timin E, Kamyar MR, Lemmens-Gruber R. Arzneimittelforschung. read more >>
  • Evaluation of risk factor management of patients treated on an internal nephrology ward: a pilot study. Stemer G, Zehetmayer S, Lemmens-Gruber R. BMC Clin Pharmacol. read more >>
  • Clinical pharmacy services and solid organ transplantation: a literature review. Stemer G, Lemmens-Gruber R. Pharm World Sci. read more >>
  • Cyclodepsipeptides from marine sponges: natural agents for drug research. Andavan GS, Lemmens-Gruber R. Mar Drugs read more >>
  • Cyclodepsipeptides - potential drugs and lead compounds in the drug development process. Lemmens-Gruber R, Kamyar MR, Dornetshuber R. Curr Med Chem. read more >>
  • Effects of the anthelmintic drug PF1022A on mammalian tissue and cells. Dornetshuber R, Kamyar MR, Rawnduzi P, Baburin I, Kouri K, Pilz E, Hornbogen T, Zocher R, Berge_r W, Lemmens-Gruber R. Biochem Pharmacol. read more >>
  • Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction. Dornetshuber R, Heffeter P, Lemmens-Gruber R, Elbling L, Marko D, Micksche M, Berge_r W. Mol Nutr Food Res. read more >>
  • Interactions between ABC-transport proteins and the secondary Fusarium metabolites enniatin and beauvericin. Dornetshuber R, Heffeter P, Sulyok M, Schumacher R, Chiba P, Kopp S, Koellensperger G, Micksche M, Lemmens-Gruber R, Berge_r W. Mol Nutr Food Res. read more >>
  • IFN-beta increases listeriolysin O-induced membrane permeabilization and death of macrophages. Zwaferink H, Stockinger S, Hazemi P, Lemmens-Gruber R, Decker T. J Immunol. read more >>
  • toxEnniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Dornetshuber R, Heffeter P, Kamyar MR, Peterbauer T, Berge_r W, Lemmens-Gruber R. Chem Res Toxicol. read more >>
  • Effects of moniliformin in presence of cyclohexadepsipeptides on isolated mammalian tissue and cells. Kamyar MR, Kouri K, Rawnduzi P, Studenik C, Lemmens-Gruber R. Toxicol In Vitro. read more >>